This discussion paper explores the intersection of cultural factors and Black women's experiences with chronic pain and suicidality. Using existing literature, we identified six domains of cultural factors potentially influencing Black women's pain experiences and suicide risk, conceptually organized into culturally specific risk factors (superwoman schema, intersectionality, history of medical mistrust) and protective factors (spirituality, culture, reliance on social support). Drawing on African American Studies, Black Psychology, and Clinical Health Psychology, we provide clear recommendations for culturally tailored interventions that can uniquely address Black women's pain and suicide-related experiences while receiving psychiatric nursing care.