This study assessed differences in risk factors for uterine cancer (UC) mortality, five-year overall survival, and independent predictors of mortality among Black and White patients treated between January 1, 2002, and December 31, 2022, at a specialized urban cancer center. Among 4,891 patients, 262 self-identified as African American or Black. Compared to non-Hispanic White patients, Black patients were more likely to experience risk factors for UC mortality. In the adjusted Cox model, older age, advanced disease, higher tumor grade, and not having graduated from high school were associated with greater mortality. Socioeconomic factors may contribute to racial disparities in UC survival; earlier diagnosis and enhanced patient support may address modifiable risk factors.